Tesofensine
Tesofensine
Description
A serotonin-norepinephrine-dopamine reuptake inhibitor originally studied as an anti-obesity agent. Promotes weight loss through appetite suppression.
Overview
Tesofensine was originally studied for neurodegenerative disease and was found to induce weight loss by reducing hunger and increasing satiety, shifting the focus toward obesity treatment.
Mechanism of Action
Tesofensine is a triple monoamine reuptake inhibitor (serotonin, noradrenaline, dopamine - SNDRI) that modulates appetite, energy expenditure, and motivation.
Benefits
- •Weight loss
- •Appetite suppression
- •Metabolic enhancement
- •Energy increase
- •Fat burning
Dosing Notes
Most weight-loss trials evaluated oral doses of 0.25, 0.5, and 1 mg/day. 0.5 mg/day showed the most balanced efficacy/tolerability; 1 mg/day produced more weight loss but more side effects.
Reported Side Effects
- •dry mouth
- •constipation
- •insomnia
- •increased heart rate
- •mild changes in blood pressure
Safety Notes
Side effects increase with dose. Because tesofensine has a very long half-life, adverse effects may persist if the dose is too high.
Scientific References
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