5-Amino-1MQ
5-Amino-1-Methylquinolinium
Description
A small molecule that inhibits NNMT enzyme, boosting NAD+ levels and cellular energy. Supports fat loss and metabolic function.
Overview
5-Amino-1MQ, or 5-amino-1-methylquinolinium, is a small molecule discovered in 2017 being researched for fat loss, muscle regeneration, and effects on cancer cells. It inhibits the NNMT enzyme, potentially raising NAD+ and SAM levels involved in energy metabolism and gene regulation. Excess NNMT activity is linked to obesity and metabolic disease. Preclinical work in mice has shown fat loss, improved metabolic markers, and muscle regeneration. It is not approved for human use and remains a research chemical.
Mechanism of Action
Inhibits nicotinamide N-methyltransferase (NNMT), increasing NAD+ and SAM availability and altering fat metabolism and muscle regeneration pathways.
Benefits
- •Fat loss
- •Energy boost
- •NAD+ enhancement
- •Metabolic support
Reported Side Effects
- •Headache
- •Nausea
- •Hypoglycemia (theoretical)
- •Limited human data
Scientific References
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