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    Tesamorelin/Ipamorelin Blend

    Research Use OnlyTesamorelin is FDA-approved for HIV-associated lipodystrophy. The combination as a compounded blend is not FDA-approved.

    Tesamorelin and Ipamorelin Blend

    Description

    A potent growth hormone secretagogue combination. Tesamorelin provides sustained GHRH stimulation while Ipamorelin adds selective GH pulsatility for optimal fat loss and muscle building.

    Dose:300 mcg/100mcg
    Frequency:5 days on, 2 days off (8 weeks on/off cycle)
    Administration Method: SQ
    CategoryWeight Loss
    Half-LifeTesamorelin ~26h; Ipamorelin ~2h.

    Overview

    Tesamorelin + Ipamorelin is a peptide blend used to support natural GH pulsatility with a metabolic focus. It is studied for reduction of visceral adipose tissue and support of lean mass.

    Mechanism of Action

    Tesamorelin is a GHRH analog that drives endogenous GH release with strong effects on metabolism and visceral fat. Ipamorelin is a selective GHRP that adds a clean pulse of GH secretion. Combined, they support natural pulsatile GH release.

    Benefits

    • Enhanced fat loss
    • Muscle building
    • GH optimization
    • Body recomposition

    Dosing Notes

    Typically self-injected subcutaneously at night to align with natural GH pulses. Cycle on ~3 months and off ~4 weeks is commonly described.

    Reported Side Effects

    • Injection-site reactions
    • Mild fluid retention or bloating
    • Joint stiffness or arthralgia
    • Myalgia
    • Peripheral edema
    • Vivid dreams
    • Increased appetite

    Safety Notes

    Not FDA-approved as a compounded blend. Can raise IGF-1; HbA1c should be checked before re-cycling. Rare reported risks include glucose intolerance, hypersensitivity, and theoretical tumor-growth stimulation.

    Scientific References

    Related Weight Loss Peptides

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