PE-22-28
PE-22-28
Description
A BDNF-derived nootropic peptide that enhances cognitive function and memory. Promotes neuroplasticity and brain health.
Overview
PE-22-28 is a synthetic pentapeptide derived from spadin, a naturally occurring TREK-1 blocker. It has enhanced stability and a longer duration of action than spadin. Water-soluble but parenteral or intranasal administration is required due to poor oral bioavailability.
Mechanism of Action
PE-22-28 selectively blocks TREK-1 potassium channels, enhancing neuronal depolarization, synaptic transmission, and firing. It promotes serotonin signaling and upregulates BDNF, supporting neuroplasticity and neurogenesis, and modulates the HPA axis to reduce stress-induced damage.
Benefits
- •Cognitive enhancement
- •Memory improvement
- •Neuroplasticity
- •Brain health
- •Learning
- •Neuroprotection
Dosing Notes
Requires parenteral or intranasal administration; oral bioavailability is poor.
Reported Side Effects
- •Injection site reactions
- •Limited human safety data
- •Possible mood effects
Safety Notes
Avoid combining with serotonergic agents - PE-22-28 enhances serotonergic signaling and could contribute to serotonin syndrome. Nasal evidence review (2026-10-25): no qualifying direct intranasal study was verified for this exact compound. Evidence for a parent peptide, another terminal modification, or a similarly named molecule must not be transferred. The previous nasal indicator was withdrawn; this is not proof that no unpublished study exists.