P21
P21
Description
A synthetic CNTF-derived peptide that promotes neurogenesis and cognitive function. Studied for neurodegenerative disease and brain health.
Overview
P21 was designed to isolate and enhance the neurogenic and neuroprotective activities of CNTF. In 3xTg-AD mice, chronic P021 treatment restored cognitive function, increased neurogenesis and synaptic markers, and reduced Aβ and tau.
Mechanism of Action
P21 (P021, Peptide 6) is a synthetic tetrapeptide mimetic of ciliary neurotrophic factor (CNTF). It is proposed to act primarily in the CNS, particularly the dentate gyrus, mimicking CNTF effects while avoiding the adverse effects of full-length CNTF.
Benefits
- •Neurogenesis
- •Cognitive enhancement
- •Memory improvement
- •Brain health
- •Depression research
- •Neuroprotection
Dosing Notes
In mouse studies, 60 nM per gram of feed has been used. Human dosing is not established.
Reported Side Effects
- •Injection site reactions
- •Headache
- •Limited long-term human data
Safety Notes
Safety in humans has not been assessed. Rodent studies up to 18 months show no weight loss, tumors, or pain signs seen with full-length CNTF. Nasal evidence review (2026-10-25): no qualifying direct intranasal study was verified for this exact compound. Evidence for a parent peptide, another terminal modification, or a similarly named molecule must not be transferred. The previous nasal indicator was withdrawn; this is not proof that no unpublished study exists.
Scientific References
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