Humanin
Humanin
Description
A mitochondria-derived peptide with cytoprotective and metabolic regulatory properties. Supports cellular stress response and longevity.
Overview
Humanin is a 24-amino-acid peptide encoded within the mitochondrial 16S rRNA gene. It has been studied for cytoprotection in Alzheimer-related cell death, insulin sensitivity, cardiovascular protection, and stress resistance.
Mechanism of Action
Humanin is a mitochondrial-derived peptide with cytoprotective properties. It influences metabolism, promotes insulin sensitivity, and modulates JAK2, STAT3, MAPK, and JNK signaling. Cytoprotective effects are largely mediated through the humanin heterotrimeric receptor complex (CNTFRα, WSX-1, gp130).
Benefits
- •Mitochondrial health
- •Cytoprotection
- •Metabolic regulation
- •Neuroprotection
- •Longevity
- •Stress response
Reported Side Effects
- •Injection site reactions
- •Limited long-term human data
Safety Notes
Nasal evidence review: humanin was administered intranasally in mouse Parkinson disease models. Human biomarker observations in the same paper are not human treatment evidence. Animal findings do not establish human nasal efficacy or safety.