ARA-290
ARA-290
Description
A tissue-protective peptide derived from erythropoietin. Shows remarkable efficacy for neuropathy, tissue healing, and inflammation reduction without erythropoietic activity.
Overview
ARA-290 is a synthetic 11-amino acid peptide derived from erythropoietin, engineered to retain tissue-protective properties while eliminating hematopoietic effects. It achieves high bioavailability via subcutaneous injection and is primarily metabolized in the liver with renal elimination. It has been studied for treating neuropathic symptoms and improving metabolic control in type 2 diabetes, and for neuropathic and autonomic symptoms in sarcoidosis.
Mechanism of Action
ARA-290 works by selectively binding to the Innate Repair Receptor (IRR) complex, which consists of CD131 and the EPO receptor. This binding activates tissue-protective signaling pathways without stimulating erythropoiesis, leading to cellular repair and survival, enhanced tissue resilience, neuroprotection, neural repair, anti-inflammatory effects, and vascular protection.
Benefits
- •Neuropathy relief
- •Tissue protection
- •Anti-inflammatory
- •Nerve regeneration
Reported Side Effects
- •Injection site reactions
- •Headache
- •Mild fatigue
Safety Notes
Nasal evidence review: a human intranasal ARA-290 pharmacokinetic study was registered, but completed results were not verified. Registration alone does not establish absorption, efficacy or nasal dose suitability.
Scientific References
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